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Microsieve membrane emulsification

PLA particles

Microsieve membrane emulsification

droplet breakup

3D CFD simulation of droplet breakup

The microsieve membrane emulsification process generates monodisperse droplets by dispersing one fluid into a second, immiscible fluid through a precise microsieve. Microsieves have millions of tiny pores that are of the same size and shape. Because of the homogeneous pore size, every droplet generated by the microsieve membrane is the same. This results in highly uniform, reproducible and size-controlled droplets. The droplets can be transformed into particles after an appropriate solidification step.

A unique feature of the microsieve membrane emulsification technology is that the droplet size is independent from the precise formulation. Which means that the size is solely determined by the membrane design. The technology offers several advantages such as:

  • optimal droplet/particle size
  • droplets 2 – 100 μm, particles 50nm – 150 μm
  • monodisperse: C.V. ≈ 5 %
    PLA microspheres

    Monodisperse PLA microspheres (10 micron-diameter) made using microsieve emulsification

  • reproducible, robust and scalable
  • encapsulation/double emulsions
  • large freedom in formulation
  • low shear and pressure
  • high chemical and thermal resistance
  • compatible with aseptic processing

Nanomi

Nanomi currently develops pharmaceutical products based on nano- and microparticles made using the microsieve emulsification process. Nanomi was co-founded by Aquamarijn and is since 2014 a subsidiary of Lupin Limited. Their microfluidic Monosphere Technology brings the precision of the semiconductor industry to the life sciences. It enables the manufacturing of uniform custom-made particles for pharmaceutical as well as life sciences specialty products. The Monosphere Technology is robust, reproducible and cost effective, from laboratory to commercial scale.

Further Reading